Histopathologic Detection of Clinically Unsuspected Cerebral Metastatic Choriocarcinoma: A Case Report

Intracerebral hemorrhage can occur due to primary and metastatic intracranial neoplasm. In half of the cases it may be the first manifestation of the tumor. It is also known that metastatic tumors bleed more than the primary CNS tumor [1]. Metastatic choriocarcinoma is a rare but an important cause of intra cerebral hemorrhage in female patients in reproductive age group. Choriocarcinoma (gestational/non-gestational) is a malignant trophoblastic disease. Incidence of gestational choriocarcinoma is 1 in 50,000 term pregnancy and 1 in 30 hydatidifirm moles. The risk of gestational choriocarcinoma is rare in females under 20 years and it is significantly increased after 40 years [2]. Non-gestational choriocarcinoma is very rare and occurs in the overies of prepubertal girls and the testes in males [3]. The usual clinical presentation of the choriocarcinoma is abnormal uterine hemorrhage after abortion or hydatidiform mole. But, rarely, intracerebral hemorrhage can be the first manifestation of it.